Genetic cancer susceptibility and DNA adducts: studies in smokers, tobacco chewers, and coke oven workers.

Preventive strategies require identification of cancer-susceptible individuals resulting from combinations of carcinogen exposure, cancer-predisposing genes, and lack of protective factors. To this aim, related to tobacco smoking and chewing (betel quid), we measured PAH-DNA adducts as exposure and susceptibility markers together with genetic polymorphism… CONTINUE READING