Genetic bottlenecks in intraspecies virus transmission.

  title={Genetic bottlenecks in intraspecies virus transmission.},
  author={John T. McCrone and Adam S Lauring},
  journal={Current opinion in virology},
Ultimately, viral evolution is a consequence of mutations that arise within and spread between infected hosts. The transmission bottleneck determines how much of the viral diversity generated in one host passes to another during transmission. It therefore plays a vital role in linking within-host processes to larger evolutionary trends. Although many studies suggest that transmission severely restricts the amount of genetic diversity that passes between individuals, there are important… CONTINUE READING
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