Genetic basis of the RhD-positive and RhD-negative blood group polymorphism as determined by Southern analysis.

@article{Colin1991GeneticBO,
  title={Genetic basis of the RhD-positive and RhD-negative blood group polymorphism as determined by Southern analysis.},
  author={Yves Colin and Baya Ch{\'e}rif-Zahar and Caroline le van Kim and Virginia Raynal and V{\'e}ronique Van Huffel and J. P. Cartron},
  journal={Blood},
  year={1991},
  volume={78 10},
  pages={2747-52}
}
Several lines of evidence have previously indicated that the RhD, c, and E blood group antigens are most likely carried by three distinct but homologous red blood cell membrane proteins. To determine whether these polypeptides are encoded by one or several related genes, we have performed Southern blot analysis of genomic DNA prepared from donors of different Rh phenotypes. Using an entire Rh cDNA probe and several exon-specific probes covering the cloned gene from its 5' to 3' ends, we have… CONTINUE READING