Genetic basis of multidrug resistance in Acinetobacter clinical isolates in Taiwan.

@article{Lin2010GeneticBO,
  title={Genetic basis of multidrug resistance in Acinetobacter clinical isolates in Taiwan.},
  author={Yu-Chi Lin and Ko-Chiang Hsia and Yee-Chun Chen and W M Sheng and S -S Chang and Mei-Hui Liao and Shu-ying Li},
  journal={Antimicrobial agents and chemotherapy},
  year={2010},
  volume={54 5},
  pages={2078-84}
}
Multidrug-resistant (MDR) Acinetobacter spp. have emerged as a threat to public health. We investigated the various genes involved in resistance to fluoroquinolones, aminoglycosides, cephalosporins, and carbapenems in 75 clinical Acinetobacter isolates from a Taiwanese hospital. All isolates were tested for the gyrA mutations, the presence of integrons, bla(AmpC), and carbapenem resistance genes. The Ser83Leu mutation in GyrA accounted for fluoroquinolone resistance. The presence of integrons… CONTINUE READING
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