Genetic basis of methicillin resistance in Staphylococcus aureus

Abstract

Methicillin resistance in staphylococci is due to the acquisition of the mecA gene encoding a new penicillin-binding protein (PBP2′, PBP2a) that has a lower affinity to methicillin than the endogenous PBPs. PBP2′ is involved in the assembly of the cell wall peptidoglycan in the presence of high concentrations of β-lactams that otherwise inhibit the… (More)
DOI: 10.1007/s000180050023

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