Genetic basis of methicillin resistance in Staphylococcus aureus

@article{BergerBchi1999GeneticBO,
  title={Genetic basis of methicillin resistance in Staphylococcus aureus},
  author={B. Berger-B{\"a}chi},
  journal={Cellular and Molecular Life Sciences CMLS},
  year={1999},
  volume={56},
  pages={764-770}
}
  • B. Berger-Bächi
  • Published 1999
  • Biology, Medicine
  • Cellular and Molecular Life Sciences CMLS
  • Abstract. Methicillin resistance in staphylococci is due to the acquisition of the mecA gene encoding a new penicillin-binding protein (PBP2′, PBP2a) that has a lower affinity to methicillin than the endogenous PBPs. PBP2′ is involved in the assembly of the cell wall peptidoglycan in the presence of high concentrations of β-lactams that otherwise inhibit the endogenous PBPs. The production of PBP2′ is under dual control by its own mecR1-mecI- and the penicillinase blaR1-blaI-encoded regulatory… CONTINUE READING

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