Genetic basis of altered central tolerance and autoimmune diseases: a lesson from AIRE mutations.


The thymus is a specialized organ that provides an inductive environment for the development of T cells from multipotent hematopoietic progenitors. Self-nonself discrimination plays a key role in inducing a productive immunity and in preventing autoimmune reactions. Tolerance represents a state of immunologic nonresponsiveness in the presence of a… (More)
DOI: 10.3109/08830185.2012.697230


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