Genetic basis of HDL variation in 129/SvImJ and C57BL/6J mice: importance of testing candidate genes in targeted mutant mice.

@article{Su2009GeneticBO,
  title={Genetic basis of HDL variation in 129/SvImJ and C57BL/6J mice: importance of testing candidate genes in targeted mutant mice.},
  author={Zhiguang Su and Xiaosong Wang and Shirng-wern Tsaih and Aihong Zhang and Allison J Cox and Susan Sheehan and Beverly J. Paigen},
  journal={Journal of lipid research},
  year={2009},
  volume={50 1},
  pages={116-25}
}
To evaluate the effect of genetic background on high-density lipoprotein cholesterol (HDL) levels in Soat1(-/-) mice, we backcrossed sterol O-acyltransferase 1 (Soat1)(-/-) mice, originally reported to have elevated HDL levels, to C57BL/6 mice and constructed a congenic strain with only a small region (3.3Mb) of 129 alleles, specifically excluding the nearby apolipoprotein A-II (Apoa2) gene from 129. HDL levels in these Soat1(-/-) mice were no different from C57BL/6, indicating that the… CONTINUE READING
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w w w .j.org D ow nladed fom 0.DC1.html http://www.jlr.org/content/suppl/2008/09/10/M800411-JLR20 Supplemental Material can be found

  • J. M. Rommens, M. C. Iannuzzi, +7 authors N. Hidaka
  • Journal of Lipid Research Volume
  • 2009

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