Genetic basis for the lack of N-glycolylneuraminic acid expression in human tissues and its implication to human evolution

@inproceedings{Suzuki2006GeneticBF,
  title={Genetic basis for the lack of N-glycolylneuraminic acid expression in human tissues and its implication to human evolution},
  author={Yusuke Suzuki},
  booktitle={Proceedings of the Japan Academy. Series B, Physical and biological sciences},
  year={2006}
}
Sialic acid is a family of acidic monosaccharides and consists of over 30 derivatives. Two major derivatives are N-acetylneuraminic acid (NeuAc) and N-glycolylneuraminic acid (NeuGc), and the hydroxylation of CMP-NeuAc is the rate limiting reaction for the production of NeuGc. The hydroxylation was carried out by a complex formed with hydroxylase, cytochrome b5, and NADH-cytochrome b5 reductase. Mouse hydroxylase was purified from the cytosolic fraction of the liver and its cDNA was cloned… CONTINUE READING

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