Genetic basis and molecular mechanism for idiopathic ventricular fibrillation

@article{Chen1998GeneticBA,
  title={Genetic basis and molecular mechanism for idiopathic ventricular fibrillation},
  author={Qiuyun Chen and Glenn E. Kirsch and Danmei Zhang and Ramon Brugada and Josep Brugada and Pedro Brugada and Domenico Potenza and Angel H Moya and Martin Borggrefe and G{\"u}nter Breithardt and Roc{\'i}o Ort{\'i}z-L{\'o}pez and Zhiqing Wang and Charles Antzelevitch and Richard E. O’Brien and Eric Schulze-Bahr and Mark T. Brookline Keating and Jeffrey A. Towbin and Qing Wang},
  journal={Nature},
  year={1998},
  volume={392},
  pages={293-296}
}
Ventricular fibrillation causes more than 300, 000 sudden deaths each year in the USA alone,. In approximately 5–12% of these cases, there are no demonstrable cardiac or non-cardiac causes to account for the episode, which is therefore classified as idiopathic ventricular fibrillation (IVF). A distinct group of IVF patients has been found to present with a characteristic electrocardiographic pattern. Because of the small size of most pedigrees and the high incidence of sudden death, however… Expand
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