Genetic background influences loss of heterozygosity patterns in radiation-induced mouse thymic lymphoma.

Abstract

Previous studies have revealed that p53 heterozygous (p53+/-) mice are extremely susceptible to radiation-induced tumorigenesis. To investigate whether genetic background influences radiation induced tumor susceptibility, we crossed p53+/- 129/Sv mice with genetically diverse strains to generate p53+/- F1 hybrids. The results showed that genetic background… (More)

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@article{Hang2015GeneticBI, title={Genetic background influences loss of heterozygosity patterns in radiation-induced mouse thymic lymphoma.}, author={Michael Hang and Yurong Huang and Antoine Snijders and Jian-Hua Mao}, journal={Journal of nature and science}, year={2015}, volume={1 5}, pages={e96} }