Genetic background effects on age-related hearing loss associated with Cdh23 variants in mice.

@article{Kane2012GeneticBE,
  title={Genetic background effects on age-related hearing loss associated with Cdh23 variants in mice.},
  author={Kelly L Kane and Chantal M. Longo-Guess and Leona H. Gagnon and Dalian Ding and Richard Salvi and Kenneth R. Johnson},
  journal={Hearing research},
  year={2012},
  volume={283 1-2},
  pages={80-8}
}
Inbred strain variants of the Cdh23 gene have been shown to influence the onset and progression of age-related hearing loss (AHL) in mice. In linkage backcrosses, the recessive Cdh23 allele (ahl) of the C57BL/6J strain, when homozygous, confers increased susceptibility to AHL, while the dominant allele (Ahl+) of the CBA/CaJ strain confers resistance. To… CONTINUE READING