Genetic background affects relative nonsense mRNA accumulation in wild-type and upf mutant yeast strains

@article{Kebaara2003GeneticBA,
  title={Genetic background affects relative nonsense mRNA accumulation in wild-type and upf mutant yeast strains},
  author={Bessie Wanja Kebaara and Tara Nazarenus and Rachel L. Taylor and Audrey L. Atkin},
  journal={Current Genetics},
  year={2003},
  volume={43},
  pages={171-177}
}
The Saccharomyces cerevisiae nonsense-mediated mRNA decay (NMD) pathway targets mRNAs with premature stop codons and some wild-type mRNAs for accelerated decay. Upf1p, Upf2p and Upf3p are required for NMD. NMD-targeted mRNAs are degraded rapidly in wild-type cells and stabilized in upf1, upf2 or upf3 mutants. We report here that the relative CYH2 pre-mRNA… CONTINUE READING