Genetic background (DDD/Sgn versus C57BL/6J) strongly influences postnatal growth of male mice carrying the Ay allele at the agouti locus: identification of quantitative trait loci associated with diabetes and body weight loss

@inproceedings{Suto2012GeneticB,
  title={Genetic background (DDD/Sgn versus C57BL/6J) strongly influences postnatal growth of male mice carrying the Ay allele at the agouti locus: identification of quantitative trait loci associated with diabetes and body weight loss},
  author={Jun-Ichi Suto and Kunio Satou},
  booktitle={BMC Genetics},
  year={2012}
}
Mice carrying the A y allele at the agouti locus become obese and are heavier than their non-A y littermates. However, this does not hold true for the genetic background of the DDD mouse strain. At 22 weeks of age, DDD.Cg-A y females are heavier than DDD females, whereas DDD.Cg-A y males are lighter than DDD males. This study aimed to determine the possible cause and identify the genes responsible for the lower body weight of DDD.Cg-A y males. Growth curves of DDD.Cg-A y mice were analyzed and… CONTINUE READING
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