Genetic augmentation of nitric oxide synthase increases the vascular generation of VEGF.

@article{Jzkowicz2001GeneticAO,
  title={Genetic augmentation of nitric oxide synthase increases the vascular generation of VEGF.},
  author={Alicja J{\'o}zkowicz and John P Cooke and Ibeth Guevara and Ihor Huk and Philipp T. Funovics and Otmar Pachinger and Franz Weidinger and Jozef Dulak},
  journal={Cardiovascular research},
  year={2001},
  volume={51 4},
  pages={773-83}
}
OBJECTIVE Vascular endothelial growth factor (VEGF) induces the release of nitric oxide (NO) from endothelial cells. There is also limited data suggesting that NO may enhance VEGF generation. METHODS To further investigate this interaction, we examined the effect of exogenous and endogenous NO on the synthesis of VEGF by rat and human vascular smooth muscle cells (VSMC) by exposing cells to exogenous NO donors, or to genetic augmentation of eNOS or iNOS. RESULTS NO-donors potentiated by 2… CONTINUE READING

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