Genetic association test for multiple traits at gene level.

  title={Genetic association test for multiple traits at gene level.},
  author={Xiaobo Guo and Zhifa Liu and Xueqin Wang and Heping Zhang},
  journal={Genetic epidemiology},
  volume={37 1},
Genome-wide association studies (GWASs) at the gene level are commonly used to understand biological mechanisms underlying complex diseases. In general, one response or outcome is used to present a disease of interest in such studies. In this study, we consider a multiple traits association test from the gene level. We propose and examine a class of test statistics that summarizes the association information between single nucleotide polymorphisms (SNPs) and each of the traits. Our simulation… CONTINUE READING
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