Genetic association studies of alcoholism--problems with the candidate gene approach.

@article{Buckland2001GeneticAS,
  title={Genetic association studies of alcoholism--problems with the candidate gene approach.},
  author={Paul R. Buckland},
  journal={Alcohol and alcoholism},
  year={2001},
  volume={36 2},
  pages={99-103}
}
In recent years, progress has been made in the identification of causative factors in most single gene disorders and those with genes of major effect. In comparison, no genes contributing to a complex disorder have been unambiguously identified. A number of reasons for this have been previously presented in theoretical papers. Alcoholism is such a complex illness and genetic studies into its underlying genetic causes have suffered from lack of power due to small subject numbers, poor selection… CONTINUE READING
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