Genetic association of vasoactive intestinal peptide receptor with rheumatoid arthritis: altered expression and signal in immune cells.

@article{Delgado2008GeneticAO,
  title={Genetic association of vasoactive intestinal peptide receptor with rheumatoid arthritis: altered expression and signal in immune cells.},
  author={Mario Delgado and Gema Robledo and B. Bryan Rueda and Nieves Varela and Francisco O'Valle and Pedro Hern{\'a}ndez-Cort{\'e}s and M P Garc{\'i}a Caro and Gisela Orozco and Elena G{\'o}nzalez-Rey and Javier Mart{\'i}n},
  journal={Arthritis and rheumatism},
  year={2008},
  volume={58 4},
  pages={1010-9}
}
OBJECTIVE Vasoactive intestinal peptide (VIP) has been shown to be one of the endogenous factors involved in the maintenance of immune tolerance. Administration of VIP ameliorates clinical signs in various experimental autoimmune disorders. This study was undertaken to investigate whether the exacerbated inflammatory autoimmune response in rheumatoid arthritis (RA) might result directly from altered expression and/or signaling of VIP receptors in immune cells. METHODS The effect of specific… CONTINUE READING

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