Genetic association of primary nonresponse to anti-TNFα therapy in patients with inflammatory bowel disease

@article{De2020GeneticAO,
  title={Genetic association of primary nonresponse to anti-TNF$\alpha$ therapy in patients with inflammatory bowel disease},
  author={T. De and H. Zhang and Cristina Alarcon and Bianca Lec and Jose W Avitia and Erin Smithberger and C. B. Chen and Melinda Horv{\'a}th and Sally Kwan and M. M. Young and Sarbani Adhikari and Jennifer Kwon and Jennifer Allen Pacheco and G. P. Jarvik and W.-q. Wei and Frank D. Mentch and Hakon H. Hakonarson and Patrick M A Sleiman and A. S. Gordon and JB Harley and Jessica Beth Linneman and Scott J. Hebbring and Loukia Parisiadou and MA Perera},
  journal={Pharmacogenetics and Genomics},
  year={2020},
  volume={32},
  pages={1 - 9}
}
Supplemental Digital Content is available in the text. Objectives Primary nonresponse (PNR) to antitumor necrosis factor-α (TNFα) biologics is a serious concern in patients with inflammatory bowel disease (IBD). We aimed to identify the genetic variants associated with PNR. Patients and methods Patients were recruited from outpatient GI clinics and PNR was determined using both clinical and endoscopic findings. A case-control genome-wide association study was performed in 589 IBD patients and… 
1 Citations
Association of anti-TNF-α treatment with gut microbiota of patients with ankylosing spondylitis
TLDR
Microbiota dysbiosis in ankylosing spondylitis patients can be restored after anti-TNF-α treatment, possibly by impacting SCFA-producing bacteria.

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