Genetic association of interleukin-6 polymorphism (-174 G/C) with chronic liver diseases and hepatocellular carcinoma.

@article{Giannitrapani2013GeneticAO,
  title={Genetic association of interleukin-6 polymorphism (-174 G/C) with chronic liver diseases and hepatocellular carcinoma.},
  author={Lydia Giannitrapani and Maurizio Soresi and Daniele Balasus and Anna Licata and Giuseppe Montalto},
  journal={World journal of gastroenterology},
  year={2013},
  volume={19 16},
  pages={2449-55}
}
Interleukin-6 (IL-6) is a pleiotropic cytokine which is expressed in many inflammatory cells in response to different types of stimuli, regulating a number of biological processes. The IL-6 gene is polymorphic in both the 5' and 3' flanking regions and more than 150 single nucleotide polymorphisms have been identified so far. Genetic polymorphisms of IL-6 may affect the outcomes of several diseases, where the presence of high levels of circulating IL-6 have been correlated to the stage and/or… CONTINUE READING
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