Genetic association of apolipoprotein E with age-related macular degeneration.

@article{Klaver1998GeneticAO,
  title={Genetic association of apolipoprotein E with age-related macular degeneration.},
  author={C. Klaver and M. Kliffen and C. V. van Duijn and A. Hofman and M. Cruts and D. Grobbee and C. van Broeckhoven and P. D. de Jong},
  journal={American journal of human genetics},
  year={1998},
  volume={63 1},
  pages={
          200-6
        }
}
Age-related macular degeneration (AMD) is the most common geriatric eye disorder leading to blindness and is characterized by degeneration of the neuroepithelium in the macular area of the eye. Apolipoprotein E (apoE), the major apolipoprotein of the CNS and an important regulator of cholesterol and lipid transport, appears to be associated with neurodegeneration. The apoE gene (APOE) polymorphism is a strong risk factor for various neurodegenerative diseases, and the apoE protein has been… Expand
435 Citations
Association of the apolipoprotein E gene with age-related macular degeneration: possible effect modification by family history, age, and gender.
  • 122
  • Highly Influenced
  • PDF
Association of apolipoprotein E alleles with susceptibility to age-related macular degeneration in a large cohort from a single center.
  • 141
  • Highly Influenced
  • PDF
Age‐related macular degeneration and functional promoter and coding variants of the apolipoprotein E gene
  • 39
  • Highly Influenced
Cholesterol and age-related macular degeneration: is there a link?
  • 113
...
1
2
3
4
5
...

References

SHOWING 1-10 OF 58 REFERENCES
Mutation of the Stargardt Disease Gene (ABCR) in Age-Related Macular Degeneration
  • 603
  • Highly Influential
  • PDF
Association of apolipoprotein E epsilon 4 allele with bulbar-onset motor neuron disease.
  • 42
Apolipoprotein E4 allele in a population–based study of early–onset Alzheimer's disease
  • 433
  • PDF
Association of apolipoprotein E ∈4 allele with bulbar-onset motor neuron disease
  • 98
Apolipoprotein E: high-avidity binding to beta-amyloid and increased frequency of type 4 allele in late-onset familial Alzheimer disease.
  • 3,929
  • PDF
Apolipoprotein E, synaptic plasticity and Alzheimer's disease.
  • 90
Mutations in the tissue inhibitor of metalloproteinases-3 (TIMP3) in patients with Sorsby's fundus dystrophy
  • 632
  • Highly Influential
Association of apolipoprotein E genotype with brain levels of apolipoprotein E and apolipoprotein J (clusterin) in Alzheimer disease.
  • 205
...
1
2
3
4
5
...