Genetic association of apolipoprotein E with age-related macular degeneration.

  title={Genetic association of apolipoprotein E with age-related macular degeneration.},
  author={C. Klaver and M. Kliffen and C. V. van Duijn and A. Hofman and M. Cruts and D. Grobbee and C. Van Broeckhoven and P. T. D. de Jong},
  journal={American journal of human genetics},
  volume={63 1},
  • C. Klaver, M. Kliffen, +5 authors P. T. D. de Jong
  • Published 1998
  • Biology, Medicine
  • American journal of human genetics
  • Age-related macular degeneration (AMD) is the most common geriatric eye disorder leading to blindness and is characterized by degeneration of the neuroepithelium in the macular area of the eye. Apolipoprotein E (apoE), the major apolipoprotein of the CNS and an important regulator of cholesterol and lipid transport, appears to be associated with neurodegeneration. The apoE gene (APOE) polymorphism is a strong risk factor for various neurodegenerative diseases, and the apoE protein has been… CONTINUE READING
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