Genetic association of apolipoprotein E with age-related macular degeneration.

@article{Klaver1998GeneticAO,
  title={Genetic association of apolipoprotein E with age-related macular degeneration.},
  author={C. Klaver and M. Kliffen and C. V. van Duijn and A. Hofman and M. Cruts and D. Grobbee and C. Van Broeckhoven and P. T. D. de Jong},
  journal={American journal of human genetics},
  year={1998},
  volume={63 1},
  pages={
          200-6
        }
}
  • C. Klaver, M. Kliffen, +5 authors P. T. D. de Jong
  • Published 1998
  • Biology, Medicine
  • American journal of human genetics
  • Age-related macular degeneration (AMD) is the most common geriatric eye disorder leading to blindness and is characterized by degeneration of the neuroepithelium in the macular area of the eye. Apolipoprotein E (apoE), the major apolipoprotein of the CNS and an important regulator of cholesterol and lipid transport, appears to be associated with neurodegeneration. The apoE gene (APOE) polymorphism is a strong risk factor for various neurodegenerative diseases, and the apoE protein has been… CONTINUE READING
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    References

    SHOWING 1-10 OF 58 REFERENCES
    Mutation of the Stargardt Disease Gene (ABCR) in Age-Related Macular Degeneration
    • 611
    • Highly Influential
    • PDF
    Association of apolipoprotein E epsilon 4 allele with bulbar-onset motor neuron disease.
    • 44
    Apolipoprotein E4 allele in a population–based study of early–onset Alzheimer's disease
    • 433
    • PDF
    Association of apolipoprotein E ∈4 allele with bulbar-onset motor neuron disease
    • 98
    Apolipoprotein E: high-avidity binding to beta-amyloid and increased frequency of type 4 allele in late-onset familial Alzheimer disease.
    • 3,918
    • PDF
    Apolipoprotein E, synaptic plasticity and Alzheimer's disease.
    • 89
    Mutations in the tissue inhibitor of metalloproteinases-3 (TIMP3) in patients with Sorsby's fundus dystrophy
    • 632
    • Highly Influential
    Association of apolipoprotein E genotype with brain levels of apolipoprotein E and apolipoprotein J (clusterin) in Alzheimer disease.
    • 205