Genetic association of an (α2-macroglobulin (Val1000lle) polymorphism and Alzheimer's disease

@inproceedings{Liao1998GeneticAO,
  title={Genetic association of an (α2-macroglobulin (Val1000lle) polymorphism and Alzheimer's disease},
  author={Andrew S. H. Liao and Roger Nitsch and Steven M. Greenberg and Ulrich Finckh and Deborah Blacker and Marilyn Albert and G. William Rebeck and Teresa G{\'o}mez-Isla and Anne E. Clatworthy and Giuliano Binetti and Christoph Hock and Tomas Mueller-Thomsen and Ulrike Mann and Krzysztof Zuchowski and Ulrike Beisiegel and Hannes B. Staehelin and John Growdon and Rudolph E Tanzi and Brad Hyman},
  year={1998}
}
α2-Macroglobulin (A2M) is a proteinase inhibitor found in association with senile plaques (SP) in Alzheimer’s disease (AD). A2M has been implicated biochemically in binding and degradation of the amyloid β (Aβ) protein which accumulates in SP. We studied the relationship between Alzheimer’s disease and a common A2M polymorphism, Val1000 (GTC)/Ile1000 (ATC), which occurs near the thiolester active site of the molecule. In an initial exploratory data set (90 controls and 171 Alzheimer’s disease… CONTINUE READING

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