Genetic association of IRF5 with SLE in Mexicans: higher frequency of the risk haplotype and its homozygozity than Europeans

@article{Reddy2007GeneticAO,
  title={Genetic association of IRF5 with SLE in Mexicans: higher frequency of the risk haplotype and its homozygozity than Europeans},
  author={M. V. Prasad Linga Reddy and Rafael Vel{\'a}zquez-Cruz and Vicente Baca and Guadalupe Lima and J. Javier Rainer Granados and Lorena Orozco and Marta E. Alarc{\'o}n-Riquelme},
  journal={Human Genetics},
  year={2007},
  volume={121},
  pages={721-727}
}
The IRF5 gene was found to be strongly associated with SLE. We identified two functional polymorphisms and recently an insertion/deletion together with a tag SNP defining the risk haplotype in individuals of European ancestry. We now analyzed sets of Mexican patients with SLE. Three polymorphisms in the IRF5 gene were genotyped in two sets of Mexican individuals with SLE and controls as well as in families including a set of pediatric SLE patients. A set of healthy Mexican Indians was also… CONTINUE READING

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