Genetic association of GABA-A receptor alpha-2 and mu opioid receptor with cocaine cue-reactivity: evidence for inhibitory synaptic neurotransmission involvement in cocaine dependence.

@article{Smelson2012GeneticAO,
  title={Genetic association of GABA-A receptor alpha-2 and mu opioid receptor with cocaine cue-reactivity: evidence for inhibitory synaptic neurotransmission involvement in cocaine dependence.},
  author={David A Smelson and Lei Yu and Steven Buyske and Gerardo Gonzalez and Jay A. Tischfield and Curtis K. Deutsch and Douglas Ziedonis},
  journal={The American journal on addictions},
  year={2012},
  volume={21 5},
  pages={411-5}
}
BACKGROUND This pilot feasibility study examined the role of genetics in laboratory-induced cocaine craving. METHODS Thirty-four African American, cocaine-depend- ent male subjects underwent a baseline assessment, cue-exposure session, and genetic analysis. Subjects were classified as either cue-reactive or nonreactive. RESULTS Among single nucleotide polymorphism markers in 13 candidate genes examined for association with cocaine cue-reactivity, two were statistically significant: GABRA2… CONTINUE READING
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