Genetic association of Ctla-4 to myasthenia gravis with thymoma.

  title={Genetic association of Ctla-4 to myasthenia gravis with thymoma.},
  author={Dedang Huang and L Liu and Kristina Nor{\'e}n and Sheng Qin Xia and Jasna Trifunovi{\'c} and Ritva Pirskanen and Ann Kari Lefvert},
  journal={Journal of neuroimmunology},
  volume={88 1-2},
Cytotoxic T lymphocyte associated antigen-4 (CTLA-4) plays a pivotal role in downregulating both the cellular and the humoral response by suppressing ongoing responses of activated T cells. Our earlier study showed that genetic variations in interleukin-1 genes confer susceptibility to myasthenia gravis, especially in patients having the lowest risk from major histocompatibility complex genes. Here we describe an association of Ctla-4 gene to the disease with thymoma and a higher prevalence of… CONTINUE READING

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