Genetic association between APOA1 and APOD polymorphisms and Alzheimer’s disease in a Japanese population

@article{Shibata2013GeneticAB,
  title={Genetic association between APOA1 and APOD polymorphisms and Alzheimer’s disease in a Japanese population},
  author={Nobuto Shibata and Tomoyuki Nagata and Shunichiro Shinagawa and Tohru Ohnuma and Hiromi Shimazaki and Masanori Komatsu and Bolati Kuerban and Katrin Tomson and Kazuhiko Nakayama and Hisashi Yamada and Hisamitsu Arai},
  journal={Journal of Neural Transmission},
  year={2013},
  volume={120},
  pages={1599-1603}
}
Alterations in lipoproteins are involved in the pathophysiology of Alzheimer’s disease (AD). For sporadic AD, the Apolipoprotein E (APOE) is recognized as a sole genetic risk factor. Apolipoprotein A1 (APOA1) has been suggested to bind amyloid β and promoter polymorphisms of the APOA1 gene were likely to affect the onset of the disease. Apolipoprotein D (APOD) expression is upregulating in AD brain and evidences showed APOD polymorphisms affect the risk for AD. The aim of this study was to… CONTINUE READING
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