Genetic aspects of Alzheimer disease

  title={Genetic aspects of Alzheimer disease},
  author={Thomas Bird},
  journal={Genetics in Medicine},
Alzheimer disease is the most common cause of dementia and represents a major public health problem. The neuropathologic findings of amyloid-β plaques and tau containing neurofibrillary tangles represent important molecular clues to the underlying pathogenesis. Genetic factors are well recognized, but complicated. Three rare forms of autosomal-dominant early-onset familial Alzheimer disease have been identified and are associated with mutations in amyloid precursor protein, presenilin 1, and… CONTINUE READING
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