Genetic architecture of transcript-level variation in humans.

  title={Genetic architecture of transcript-level variation in humans.},
  author={Shiwei Duan and R. Stephanie Huang and Wei Zhang and Wasim Kamel Bleibel and Cheryl A Roe and Tyson A Clark and Tina X. Chen and Anthony C. Schweitzer and John Blume and Nancy J. Cox and M. Eileen Dolan},
  journal={American journal of human genetics},
  volume={82 5},
We report here the results of testing the pairwise association of 12,747 transcriptional gene-expression values with more than two million single-nucleotide polymorphisms (SNPs) in samples of European (CEPH from Utah; CEU) and African (Yoruba from Ibadan; YRI) ancestry. We found 4,677 and 5,125 significant associations between expression quantitative nucleotides (eQTNs) and transcript clusters in the CEU and the YRI samples, respectively. The physical distance between an eQTN and its associated… CONTINUE READING

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