Genetic architecture of ambulatory blood pressure in the general population: insights from cardiovascular gene-centric array.

@article{Tomaszewski2010GeneticAO,
  title={Genetic architecture of ambulatory blood pressure in the general population: insights from cardiovascular gene-centric array.},
  author={Maciej Tomaszewski and Radoslaw Debiec and Peter S. Braund and Christopher P. Nelson and Robert Hardwick and Paraskevi Christofidou and Matthew Denniff and Veryan Codd and Suzanne E Rafelt and Pim van der Harst and Dawn Waterworth and Kijoung Song and Peter Vollenweider and G{\'e}rard Waeber and E A Zukowska-szczechowska and Paul R. Burton and Vincent E. Mooser and Fadi Charchar and John R. Thompson and Martin D Tobin and Nilesh J. Samani},
  journal={Hypertension},
  year={2010},
  volume={56 6},
  pages={1069-76}
}
Genetic determinants of blood pressure are poorly defined. We undertook a large-scale, gene-centric analysis to identify loci and pathways associated with ambulatory systolic and diastolic blood pressure. We measured 24-hour ambulatory blood pressure in 2020 individuals from 520 white European nuclear families (the Genetic Regulation of Arterial Pressure of Humans in the Community Study) and genotyped their DNA using the Illumina HumanCVD BeadChip array, which contains ≈ 50 000 single… CONTINUE READING

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