Genetic approaches to understanding human obesity.

  title={Genetic approaches to understanding human obesity.},
  author={Shwetha Ramachandrappa and I Sadaf Farooqi},
  journal={The Journal of clinical investigation},
  volume={121 6},
Obesity and its associated comorbidities represent one of the biggest public health challenges facing the world today. The heritability of body weight is high, and genetic variation plays a major role in determining the interindividual differences in susceptibility or resistance to the obesogenic environment. Here we discuss how genetic studies in humans have contributed to our understanding of the central pathways that govern energy homeostasis. We discuss how the arrival of technological… CONTINUE READING
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