Genetic approaches to the neurobiology of electroconvulsive therapy.

  title={Genetic approaches to the neurobiology of electroconvulsive therapy.},
  author={Laura J. Fochtmann},
  journal={The journal of ECT},
  volume={14 3},
Although electroconvulsive therapy effectively treats severe psychiatric disorders, its neurobiologic mechanisms are not fully understood. Also unclear is the basis for variability in seizure threshold and duration among patients. We used multiple strains of rats and mice to test for genetic variation in the properties of seizures induced by electroconvulsive shock (ECS). We specifically measured seizure duration, sensitivity to proconvulsant actions of caffeine, and relative refractoriness to… CONTINUE READING