Genetic approaches to the determination of structure-function relationships of G protein-coupled receptors.

@article{Strader1989GeneticAT,
  title={Genetic approaches to the determination of structure-function relationships of G protein-coupled receptors.},
  author={Catherine D. Strader and Irving S. Sigal and Richard Alastair Dixon},
  journal={Trends in pharmacological sciences},
  year={1989},
  volume={Suppl},
  pages={26-30}
}
The beta-adrenergic receptor (beta AR), which has been extensively characterized pharmacologically, serves as a useful model system for the analysis of the structure-function relationships of G protein-coupled receptors. Genetic and biochemical analysis has revealed that the ligand binding domain of the receptor involves residues within the hydrophobic… CONTINUE READING