Genetic approaches to functional gastrointestinal disorders.

  title={Genetic approaches to functional gastrointestinal disorders.},
  author={Y A Saito and Nandita Mitra and Emeran A. Mayer},
  volume={138 4},
Functional gastrointestinal disorders are complex symptom-based disorders without agreed upon biomarkers or pathophysiology. A better understanding of the genetic architecture of these disorders would help to better identify their complex biology and explain the common comorbidity with other disorders of persistent pain, mood, and affect, as well as possibly make it possible to identify subgroups of patients who respond to customized therapies. In contrast to monogenic diseases, polygenic… CONTINUE READING


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