Genetic approach to male meiotic division deficiency: the human macronuclear spermatozoa.

@article{Escalier2002GeneticAT,
  title={Genetic approach to male meiotic division deficiency: the human macronuclear spermatozoa.},
  author={Denise Escalier},
  journal={Molecular human reproduction},
  year={2002},
  volume={8 1},
  pages={1-7}
}
Human macronuclear spermatozoa (also termed large-headed or macrocephalic spermatozoa) are tetraploid and represent a mammalian model of meiotic division deficiency (MDD). Their genetic origin is strongly suggested by the existence of familial cases. They arise from spermatocytes I with a blockage of organelle displacement at the pachytene stage which disables the assembly of a bipolar meiotic spindle. Spermiogenesis can sometimes be complete, showing that meiotic divisions and spermiogenesis… CONTINUE READING

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Microtubular disorders in human spermatozoa

  • D. Escalier
  • 1985
Highly Influential
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