Genetic and post-mortem mRNA analysis of the 14-3-3 genes that encode phosphoserine/threonine-binding regulatory proteins in schizophrenia and bipolar disorder.

@article{Wong2005GeneticAP,
  title={Genetic and post-mortem mRNA analysis of the 14-3-3 genes that encode phosphoserine/threonine-binding regulatory proteins in schizophrenia and bipolar disorder.},
  author={Albert Hung Choy Wong and Olga Likhodi and Joseph M. Trakalo and Muneeb Yusuf and Anuradha Sinha and Carlos N. Pato and Michele T. Pato and Hubert H M Van Tol and James L Kennedy},
  journal={Schizophrenia research},
  year={2005},
  volume={78 2-3},
  pages={137-46}
}
BACKGROUND Previous work with animal models of psychosis, human genetic studies, and human post-mortem gene expression studies implicate the 14-3-3 family of genes in schizophrenia. The 14-3-3 genes code for a family of proteins that bind to and regulate other proteins, and they modulate neurodevelopment, cell-division, signal transduction and gene transcription. OBJECTIVE To explore the role of five 14-3-3 isoforms (beta, gamma, epsilon, zeta, and eta) in schizophrenia by: (1) comparing mRNA… CONTINUE READING

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