Genetic and physiological association of diabetes susceptibility with raised Na+/H+ exchange activity.

@article{Morahan1994GeneticAP,
  title={Genetic and physiological association of diabetes susceptibility with raised Na+/H+ exchange activity.},
  author={Grant Morahan and Peter J. McClive and Dexing Huang and Peter Little and Alan G. Baxter},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={1994},
  volume={91 13},
  pages={5898-902}
}
Insulin-dependent diabetes mellitus is a multigenic autoimmune disease, for which one of the best animal models is the nonobese diabetic (NOD) mouse strain. In both humans and NOD mice, major histocompatibility complex genes are implicated as risk factors in the disease process. Other susceptibility genes are also involved, and a number have been mapped in the mouse to specific chromosomal locations. To identify further susceptibility genes, diabetic backcross mice, produced after crossing NOD… CONTINUE READING