Genetic and physiologic modulation of the prestarvation response in Dictyostelium discoideum.

@article{Burdine1995GeneticAP,
  title={Genetic and physiologic modulation of the prestarvation response in Dictyostelium discoideum.},
  author={V Burdine and Mairi Clarke},
  journal={Molecular biology of the cell},
  year={1995},
  volume={6 3},
  pages={
          311-25
        }
}
Throughout vegetative growth, Dictyostelium amoebae secrete an autocrine factor, prestarvation factor, PSF, which accumulates in proportion to cell density. During late exponential growth, PSF induces the expression of several genes whose products are needed for cAMP signaling and cell aggregation. Among these genes are discoidin-I and the 2.4-kb transcript of cyclic nucleotide phosphodiesterase (PDE). We have identified several parameters that modulate expression of one or both of these… CONTINUE READING
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