Genetic and physical analyses of the centromeric and pericentromeric regions of human chromosome 5: recombination across 5cen.

@article{Puechberty1999GeneticAP,
  title={Genetic and physical analyses of the centromeric and pericentromeric regions of human chromosome 5: recombination across 5cen.},
  author={Jacques Puechberty and A M Laurent and Sylvie Gimenez and Alain Billault and M E Brun-Laurent and A Calenda and Bertrand Marçais and Catherine Prades and Panos A. Ioannou and Yuri B. Yurov and G{\'e}rard Roizes},
  journal={Genomics},
  year={1999},
  volume={56 3},
  pages={274-87}
}
Human centromeres are poorly understood at both the genetic and the physical level. In this paper, we have been able to distinguish the alphoid centromeric sequences of chromosome 5 from those of chromosome 19. This result was obtained by pulsed-field gel electrophoresis after cutting genomic DNA with restriction endonucleases NcoI (chromosome 5) and BamHI (chromosome 19). We could thus define a highly polymorphic marker, representing length variations of the D5Z1 domain located at the q arm… CONTINUE READING
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