Genetic and phenotypic overlap of specific obsessive-compulsive and attention-deficit/hyperactive subtypes with Tourette syndrome

  title={Genetic and phenotypic overlap of specific obsessive-compulsive and attention-deficit/hyperactive subtypes with Tourette syndrome},
  author={Matthew E. Hirschtritt and Sabrina Michelle Darrow and Cornelia L. Illmann and Lisa Osiecki and Marco A. Grados and Paul Sandor and Yves Dion and Robert A. King and David L. Pauls and Cathy L. Budman and Danielle C. Cath and Erica Greenberg and Gholson J. Lyon and D. Yu and Lauren M. McGrath and William M. McMahon and P. C. Lee and Kevin L. Delucchi and Jeremiah M. Scharf and Carol A. Mathews},
  journal={Psychological Medicine},
  pages={279 - 293}
Background The unique phenotypic and genetic aspects of obsessive-compulsive (OCD) and attention-deficit/hyperactivity disorder (ADHD) among individuals with Tourette syndrome (TS) are not well characterized. Here, we examine symptom patterns and heritability of OCD and ADHD in TS families. Method OCD and ADHD symptom patterns were examined in TS patients and their family members (N = 3494) using exploratory factor analyses (EFA) for OCD and ADHD symptoms separately, followed by latent class… 
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Challenges in the Diagnosis and Assessment in Patients with Tourette Syndrome and Comorbid Obsessive-Compulsive Disorder
Current state of the art regarding diagnosis and assessment of tic and OCD in patients with TS as well as challenges related to differential diagnosis between tics and OCD-related phenomena are discussed based on a systematic literature search.
The Behavioral and Emotional Profile of Pediatric Tourette Syndrome Based on CBCL in a Chinese Sample
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Tourette's disorder in children and adolescents.
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Trichotillomania is more related to Tourette disorder than to obsessive-compulsive disorder
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The past decade's literature is reviewed and a critical commentary on the involvement of immunological mechanisms in normal brain development, as well as its role in the pathophysiology of Tourette syndrome, other Chronic tic disorders, and related neuropsychiatric disorders including Obsessive-compulsive disorder (OCD) and Attention deficit hyperactivity disorder (ADHD).


Familiality of Tourette syndrome, obsessive-compulsive disorder, and attention-deficit/hyperactivity disorder: heritability analysis in a large sib-pair sample.
  • C. Mathews, M. Grados
  • Psychology, Biology
    Journal of the American Academy of Child and Adolescent Psychiatry
  • 2011
Comorbidity Between Attention Deficit/Hyperactivity Disorder and Obsessive-Compulsive Disorder Across the Lifespan: A Systematic and Critical Review
Clinicians are encouraged to consider the possibility that ADHD-like symptoms resulting from OCD-specific symptomatology may be misdiagnosed as ADHD, which may account for the lower co-occurrence rates reported in adolescents and adults and for the lack of a theoretical account for comorbidity in these age groups.
Identification of Two Heritable Cross-Disorder Endophenotypes for Tourette Syndrome.
The symmetry phenotype correlated with Tourette Syndrome polygenic load and was present in otherwise Tourette-unaffected mothers, suggesting that this phenotype may reflect additional Tourette syndrome genetic liability that is not captured by traditional DSM-based diagnoses.
Confirmatory Factor Analyses Examining Attention Deficit Hyperactivity Disorder Symptoms and Other Childhood Disruptive Behaviors
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There is an important unitary component to ADHD symptoms and separable dimensional traits of Inattention and Hyperactivity/Impulsivity, which suggest that the findings are not method– or informant-specific.
Clinical phenomenology and phenotype variability in Tourette syndrome.
Copy number variation in obsessive-compulsive disorder and tourette syndrome: a cross-disorder study.
Symptom Dimensions in OCD: Item-Level Factor Analysis and Heritability Estimates
The results support the utility of both OCD diagnosis and symptom dimensions in genetic research and clinical contexts and both shared and unique genetic influences underlie susceptibility to OCD and its symptom dimensions.