Genetic and phenotypic overlap of specific obsessive-compulsive and attention-deficit/hyperactive subtypes with Tourette syndrome

@article{Hirschtritt2017GeneticAP,
  title={Genetic and phenotypic overlap of specific obsessive-compulsive and attention-deficit/hyperactive subtypes with Tourette syndrome},
  author={Matthew E. Hirschtritt and Sabrina Michelle Darrow and Cornelia L. Illmann and Lisa Osiecki and Marco A. Grados and Paul Sandor and Yves Dion and Robert A. King and David L. Pauls and Cathy L. Budman and Danielle C. Cath and Erica Greenberg and Gholson J. Lyon and D. Yu and Lauren M. McGrath and William M. McMahon and P. C. Lee and Kevin L. Delucchi and Jeremiah M. Scharf and Carol A. Mathews},
  journal={Psychological Medicine},
  year={2017},
  volume={48},
  pages={279 - 293}
}
Background The unique phenotypic and genetic aspects of obsessive-compulsive (OCD) and attention-deficit/hyperactivity disorder (ADHD) among individuals with Tourette syndrome (TS) are not well characterized. Here, we examine symptom patterns and heritability of OCD and ADHD in TS families. Method OCD and ADHD symptom patterns were examined in TS patients and their family members (N = 3494) using exploratory factor analyses (EFA) for OCD and ADHD symptoms separately, followed by latent class… 
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31 Citations
Background Citations
12
Methods Citations
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31 Citations

Citation Type

Citation Type

Polygenic Heterogeneity Across Obsessive-Compulsive Disorder Subgroups Defined by a Comorbid Diagnosis
TLDR
It is found that PRS of all traits but BMI were significantly associated with OCD across all subgroups and the correlation patterns that emerged from genetic correlation analysis of OCD, MDD, ADHD, and ASD were mirrored in the PRS associations with the respective comorbid OCD groups.
Challenges in the Diagnosis and Assessment in Patients with Tourette Syndrome and Comorbid Obsessive-Compulsive Disorder
TLDR
Current state of the art regarding diagnosis and assessment of tic and OCD in patients with TS as well as challenges related to differential diagnosis between tics and OCD-related phenomena are discussed based on a systematic literature search.
The Behavioral and Emotional Profile of Pediatric Tourette Syndrome Based on CBCL in a Chinese Sample
TLDR
Based on the assessment of the Child Behavior Checklist of TS, it was found that “pure” TS might show fewer behavioral and emotional problems than OCD, ADHD, and MDD.
Tourette's disorder in children and adolescents.
TLDR
Concepts of management are considered including behavioral therapy and pharmacologic approaches with alpha-adrenoceptor agonists, atypical antipsychotics (AAs), haloperidol, pimozide and others.
A dimensional perspective on the genetics of obsessive-compulsive disorder
This review covers recent findings in the genomics of obsessive-compulsive disorder (OCD), obsessive-compulsive symptoms, and related traits from a dimensional perspective. We focus on discoveries…
Capturing Subtle Neurocognitive Differences in Children with and without Tourette Syndrome through a Fine-Grained Analysis of Design Fluency Profiles
TLDR
Children with TS do not inherently show general executive dysfunction but may present with subtle neurocognitive characteristics here revealed by comprehensive design fluency profiles, presumably sensitive to frontostriatal dysfunction.
Elevated levels of hoarding in ADHD: a special link with inattention
The efficacy and neural correlates of ERP-based therapy for OCD & TS: A systematic review and meta-analysis
TLDR
ERP-based therapy is effective for patients with OCD and TS/chronic tic disorder and a combination with other therapies and the development of online ERP services that might prove a promising new direction for healthcare providers are suggested.
Trichotillomania is more related to Tourette disorder than to obsessive-compulsive disorder
TLDR
A closer relationship is found between trichotillomania and tic disorder from neurobiological (especially imaging) and therapeutic standpoints and several arguments are in favor of a closer relationship between these two disorders than between TTM and OCD, especially when considering implications for therapy.
What Does Immunology Have to Do With Normal Brain Development and the Pathophysiology Underlying Tourette Syndrome and Related Neuropsychiatric Disorders?
TLDR
The past decade's literature is reviewed and a critical commentary on the involvement of immunological mechanisms in normal brain development, as well as its role in the pathophysiology of Tourette syndrome, other Chronic tic disorders, and related neuropsychiatric disorders including Obsessive-compulsive disorder (OCD) and Attention deficit hyperactivity disorder (ADHD).
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