Genetic and phenotypic intra-species variation in Candida albicans.

  title={Genetic and phenotypic intra-species variation in Candida albicans.},
  author={Matthew P. Hirakawa and Diego A Martinez and Sharadha Sakthikumar and Matthew Z Anderson and Aaron M. Berlin and Sharvari Gujja and Qiandong Zeng and Ethan Zisson and Joshua M Wang and Joshua M Greenberg and Judith Berman and Richard J. Bennett and Christina A Cuomo},
  journal={Genome research},
  volume={25 3},
Candida albicans is a commensal fungus of the human gastrointestinal tract and a prevalent opportunistic pathogen. To examine diversity within this species, extensive genomic and phenotypic analyses were performed on 21 clinical C. albicans isolates. Genomic variation was evident in the form of polymorphisms, copy number variations, chromosomal inversions, subtelomeric hypervariation, loss of heterozygosity (LOH), and whole or partial chromosome aneuploidies. All 21 strains were diploid… CONTINUE READING
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