Genetic and phenotypic heterogeneity of human malignancies: finding order in chaos.

@article{Shackney1995GeneticAP,
  title={Genetic and phenotypic heterogeneity of human malignancies: finding order in chaos.},
  author={Stanley Shackney and T. Vincent Shankey},
  journal={Cytometry},
  year={1995},
  volume={21 1},
  pages={
          2-5
        }
}
The presence of cellular heterogeneity within human tumors has been recognized for many years. Current concepts regarding the clonal origin of human neoplasms, and recent advances in the study of successive genetic changes that occur during tumor evolution may now make it possible to understand in greater depth the biological and clinical implications of intra-tumor heterogeneity at both the phenotypic and genotypic levels. In order to explore these concepts further, and to better identify the… CONTINUE READING

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