Genetic and pharmacological reactivation of the mammalian inactive X chromosome

@inproceedings{Bhatnagara2014GeneticAP,
  title={Genetic and pharmacological reactivation of the mammalian inactive X chromosome},
  author={Sanchita Bhatnagara and Xiaochun Zhua and Jianhong Oub and Ling Lina and Lynn Chamberlaina and Lihua J. Zhub and Narendra Wajapeyeee and Michael R. Greena},
  year={2014}
}
  • Sanchita Bhatnagara, Xiaochun Zhua, +5 authors Michael R. Greena
  • Published 2014
X-chromosome inactivation (XCI), the random transcriptional silencing of one X chromosome in somatic cells of female mammals, is a mechanism that ensures equal expression of X-linked genes in both sexes. XCI is initiated in cis by the noncoding Xist RNA, which coats the inactive X chromosome (Xi) from which it is produced. However, trans-acting factors that… CONTINUE READING