Genetic and pharmacological intervention of the p75NTR pathway alters morphological and behavioural recovery following traumatic brain injury in mice.

@article{Alder2016GeneticAP,
  title={Genetic and pharmacological intervention of the p75NTR pathway alters morphological and behavioural recovery following traumatic brain injury in mice.},
  author={Janet Alder and Wendy Fujioka and Anna Giarratana and Jenna Wissocki and Keya Thakkar and Phung Vuong and Bijal M. Patel and Trisha Chakraborty and Rami Elsabeh and Ankit Parikh and Hartaj S Girn and David P Crockett and Smita Thakker-Varia},
  journal={Brain injury},
  year={2016},
  volume={30 1},
  pages={
          48-65
        }
}
PRIMARY OBJECTIVE Neurotrophin levels are elevated after TBI, yet there is minimal regeneration. It was hypothesized that the pro-neurotrophin/p75NTR pathway is induced more than the mature neurotrophin/Trk pathway and that interfering with p75 signalling improves recovery following TBI. RESEARCH DESIGN Lateral Fluid Percussion (LFP) injury was performed on wildtype and p75 mutant mice. In addition, TrkB agonist 7,8 Dihydroxyflavone or p75 antagonist TAT-Pep5 were tested. Western blot and… CONTINUE READING

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