Genetic and pharmacological factors that influence reproductive aging in nematodes.

@article{Hughes2005GeneticAP,
  title={Genetic and pharmacological factors that influence reproductive aging in nematodes.},
  author={Stacie E Hughes and Kimberley Evason and Chengjie Xiong and Kerry Kornfeld},
  journal={PLoS genetics},
  year={2005},
  volume={3 2},
  pages={
          e25
        }
}
Age-related degenerative changes in the reproductive system are an important aspect of aging, because reproductive success is the major determinant of evolutionary fitness. Caenorhabditis elegans is a prominent organism for studies of somatic aging, since many factors that extend adult lifespan have been identified. However, mechanisms that control reproductive aging in nematodes or other animals are not well characterized. To use C. elegans to measure reproductive aging, we analyzed mated… CONTINUE READING

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