Genetic and pharmacological evidence for more than one human steroid 5 alpha-reductase.

@article{Jenkins1992GeneticAP,
  title={Genetic and pharmacological evidence for more than one human steroid 5 alpha-reductase.},
  author={Elizabeth P. Jenkins and S. Torgny Andersson and Julianne L Imperato-McGinley and J Douglas Wilson and D. W. Russell},
  journal={The Journal of clinical investigation},
  year={1992},
  volume={89 1},
  pages={293-300}
}
The enzyme steroid 5 alpha-reductase catalyzes the conversion of testosterone into the more potent androgen, dihydrotestosterone, and impairment of this reaction causes a form of male pseudohermaphroditism in which genetic males differentiate predominantly as phenotypic females. We previously isolated cDNA clones that encode a human steroid 5 alpha-reductase enzyme. Here, we report molecular and genetic studies demonstrating that the gene encoding this cDNA is normal in subjects with the… CONTINUE READING