Genetic and pharmacologic inhibition of mTORC1 promotes EMT by a TGF-β-independent mechanism.

@article{Mikalian2013GeneticAP,
  title={Genetic and pharmacologic inhibition of mTORC1 promotes EMT by a TGF-β-independent mechanism.},
  author={Ivan Mika{\'e}lian and Mouhannad Malek and Rudy Gadet and Jean Viallet and Amandine I Garcia and Ana{\"i}s Girard-Gagnepain and C{\'e}dric Hesling and Germain Gillet and Philippe Gonzalo and Ruth Rimokh and Marc Billaud},
  journal={Cancer research},
  year={2013},
  volume={73 22},
  pages={
          6621-31
        }
}
Epithelial-to-mesenchymal transition (EMT) is a transdifferentiation process that converts epithelial cells into highly motile mesenchymal cells. This physiologic process occurs largely during embryonic development but is aberrantly reactivated in different pathologic situations, including fibrosis and cancer. We conducted a siRNA screening targeted to the human kinome with the aim of discovering new EMT effectors. With this approach, we have identified mTOR complex 1 (mTORC1), a nutrient… CONTINUE READING

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