Genetic and other factors determining mannose-binding lectin levels in American Indians: the Strong Heart Study

@article{Best2008GeneticAO,
  title={Genetic and other factors determining mannose-binding lectin levels in American Indians: the Strong Heart Study},
  author={Lyle G. Best and Robert E. Ferrell and S Decroo and Kari E. North and Jean W Maccluer and Ying Zhang and E. T. Lee and Barbara V Howard and Jason G Umans and Vittorio G. Palmieri and Peter Garred},
  journal={BMC Medical Genetics},
  year={2008},
  volume={10},
  pages={5 - 5}
}
Mannose-binding lectin (MBL) forms an integral part of the innate immune system. Persistent, subclinical infections and chronic inflammatory states are hypothesized to contribute to the pathogenesis of atherosclerosis. MBL gene (MBL2) variants with between 12 to 25% allele frequency in Caucasian and other populations, result in markedly reduced expression… CONTINUE READING