Genetic and neuroanatomic associations in sporadic frontotemporal lobar degeneration

@article{McMillan2014GeneticAN,
  title={Genetic and neuroanatomic associations in sporadic frontotemporal lobar degeneration},
  author={Corey T McMillan and Jon B. Toledo and Brian B. Avants and Philip A. Cook and Murray Grossman},
  journal={Neurobiology of Aging},
  year={2014},
  volume={35},
  pages={1473-1482}
}
Genome-wide association studies have identified single nucleotide polymorphisms (SNPs) that are sensitive for tau or TDP-43 pathology in frontotemporal lobar degeneration (FTLD). Neuroimaging analyses have revealed distinct distributions of disease in FTLD patients with genetic mutations. However, genetic influences on neuroanatomic structure in sporadic FTLD have not been assessed. In this report, we use novel multivariate tools, Eigenanatomy, and sparse canonical correlation analysis to… CONTINUE READING
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