Genetic and molecular genetic studies of murine and human lupus.

  title={Genetic and molecular genetic studies of murine and human lupus.},
  author={Alfred D. Steinberg and Dennis M Klinman and Daniel L. Kastner and Michael F. Seldin and William C. Gause and Curtis L. Scribner and J L Britten and Joan N Siegel and John D. Mountz},
  journal={The Journal of rheumatology. Supplement},
  volume={14 Suppl 13},
Mice and humans with systemic lupus erythematosus (SLE) have been studied with regard to cellular, genetic and molecular genetic abnormalities. B cell hyperactivity and autoantibody production are the hallmarks of this illness. In humans with SLE, there is increased stem cell, B cell precursor and B cell proliferation. The same is true of NZB mice. In lpr/lpr and gld/gld mice, marked expansion of a subpopulation of T cells allows extrathymic terminal T cell maturation and secondary B cell… CONTINUE READING